THE BEST SIDE OF METHADONE DRUG CLASS

[sixty one] Like numerous other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that's much less strong being an opioid, is much more powerful at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone features a lower affinity, with